There is evidence that chromium picolinate may help off set some of the symptoms of atypical depression. Often sufferers of the disease face carb cravings, increasedeating and weight gain.  Chromium picolinate has been shown to besuccessful in curbing each of these symptoms.  It is importantthat supplements such as this not be seen as a treatment fordepression.  If you think that chromium picolinate might be foryou, consult with your psychiatrist on the best course of action.